ABSTRACT
Liver dysfunction is highlighted by several studies as a relevant complication in the context of coronavirus disease 2019 (COVID-19). We present a pediatric patient with mild phenotype but transient severe liver injury. Hepatic damage should be considered even in mild cases of the disease to ensure prompt recognition and management.
Subject(s)
COVID-19/physiopathology , Liver Diseases/virology , COVID-19/virology , Child, Preschool , Humans , Liver Diseases/physiopathology , Male , SARS-CoV-2/isolation & purification , Severity of Illness IndexABSTRACT
Diet modification to increase water and fiber consumption is considered an important component in the management of constipation. This prospective randomized study aimed to evaluate the compliance of 86 children with refractory functional constipation (mean age 4.4 years, range 1 to 11 years)-to a high-fiber, high-water diet following either physician's dietary advice (PI group) (n=42) or physician's dietary advice plus personalized diet management by a registered dietitian (DM group) (n=44). Dietary intake was assessed by a 24-hour dietary recall at baseline and 1 month later. The changes in water and fiber consumption were used as compliance criteria. DM group had comparable anthropometric measurements; sex distribution; and baseline intakes of energy, macronutrient, water, and dietary fiber compared with the PI group. Comparison of nutrient intakes between the two visits within each group showed a significant increase in fiber consumption in both groups that was more pronounced in the DM group. Water, energy, and carbohydrate consumption increased significantly only in the DM group. Multivariate regression analysis revealed that the intervention group was the only significant independent predictor for the change in fiber and water consumption after controlling for age, sex, and weight-for-age z score. Children receiving personalized diet management for refractory functional constipation achieved better compliance in increasing fiber and water consumption.
Subject(s)
Constipation/diet therapy , Dietary Fiber/therapeutic use , Dietetics/methods , Drinking , Patient Compliance , Precision Medicine/methods , Child , Child, Preschool , Constipation/drug therapy , Constipation/prevention & control , Diet, Mediterranean , Drug Resistance , Female , Greece , Humans , Infant , Lactulose/therapeutic use , Laxatives , Male , Patient Education as Topic , Practice Guidelines as Topic , Secondary PreventionABSTRACT
The aim of this study was to assess the serum concentrations of Clara cell secretory protein (CC16) in association with acute and chronic lung injury in mechanically ventilated preterm neonates. Thirty-five preterm neonates (gestational age [GA] Subject(s)
Lung Diseases/etiology
, Lung Diseases/genetics
, Respiration, Artificial
, Respiratory Distress Syndrome/therapy
, Uteroglobin/blood
, Uteroglobin/genetics
, Genetic Markers
, Humans
, Infant, Newborn
, Infant, Premature
, Lung Diseases/epidemiology
, Mass Screening/methods
, Neonatal Screening
, Prospective Studies
, Respiratory Distress Syndrome/epidemiology
, Respiratory Distress Syndrome/genetics
ABSTRACT
Brucellosis represents a rare cause of neonatal infection. In this article we report a very unusual case of congenital infection due to BRUCELLA MELITENSIS in a term neonate presenting after birth with severe respiratory distress and radiological manifestations (lobar consolidation and diffuse interstitial infiltrations) compatible with pulmonary involvement. The neonate was successfully treated with trimethoprim-sulfamethoxazole, rifampicin, and gentamicin.
